Genetic Testing and Screening in Ahmedabad

Genetic Testing and Screening for IVF in Ahmedabad

Every healthy pregnancy begins with healthy genes. At Ayuh Fertility Centre, Ahmedabad, under the expert care of Dr. Krupa Shah, we provide advanced genetic testing and screening services designed to identify genetic or chromosomal conditions that may affect fertility, embryo health, or pregnancy outcomes.

Our goal is to help couples make informed decisions before conception or IVF treatment, ensuring a higher success rate and a lower risk of inherited disorders. Using cutting-edge reproductive genetics and non-invasive technologies, we ensure accuracy, safety, and peace of mind for every patient.

Whether you’re undergoing IVF, have a family history of genetic conditions, or have experienced multiple miscarriages, Dr. Krupa Shah guides you through every step with compassion, transparency, and clarity. At Ayuh, genetic testing is not just about science — it’s about giving your family the healthiest possible start to life.

What Is Preimplantation Genetic Testing (PGT)?

Preimplantation Genetic Testing (PGT) is an advanced embryo screening technique performed during an IVF cycle. Before embryo transfer, a few cells are biopsied from the embryo and tested for chromosomal abnormalities or specific genetic mutations. This allows our embryologists at Ayuh Fertility Centre to select only the healthiest, genetically normal embryos for transfer — significantly improving the chances of a successful pregnancy and a healthy baby.

PGT is recommended for couples at risk of passing on genetic disorders, women of advanced maternal age, and patients who have experienced recurrent miscarriages or repeated IVF failures.

PGT-A — Testing for Chromosomal Abnormalities

PGT-A (Preimplantation Genetic Testing for Aneuploidy) screens embryos for an abnormal number of chromosomes — a condition called aneuploidy. Chromosomally abnormal embryos are the leading cause of IVF failure and early miscarriage. Using Next Generation Sequencing (NGS) technology, PGT-A identifies embryos with the correct number of chromosomes (46 total — 23 pairs), ensuring only euploid (normal) embryos are transferred. This is particularly beneficial for women over 35 and those with a history of recurrent pregnancy loss.

PGT-M — Testing for Single Gene Disorders

PGT-M (Preimplantation Genetic Testing for Monogenic/Single Gene Disorders) is used when one or both parents carry a known genetic mutation — such as thalassemia, sickle cell anaemia, cystic fibrosis, Huntington's disease, or spinal muscular atrophy (SMA). PGT-M tests embryos for that specific mutation before transfer, allowing couples to have a biological child free from the inherited condition. It requires careful genetic counselling and preparation before the IVF cycle begins.

PGT-SR — Structural Chromosomal Rearrangements

PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements) is recommended when one parent carries a chromosomal structural rearrangement such as a translocation or inversion. These rearrangements may not affect the parent but can cause serious chromosomal imbalances in embryos, leading to miscarriage or a child born with chromosomal conditions. PGT-SR identifies structurally normal or balanced embryos to improve IVF outcomes.

Carrier Screening — Know Your Genetic Risk Before IVF

Carrier screening tests prospective parents for genetic mutations they may carry without showing symptoms themselves. Conditions such as beta-thalassemia are highly prevalent in Gujarat and across India. If both parents are carriers of the same recessive condition, each pregnancy has a 25% chance of being affected. At Ayuh, we recommend carrier screening before or during your IVF cycle, especially for couples from communities with higher carrier rates. Early knowledge empowers better reproductive decisions.

Who Should Consider Genetic Testing Before IVF?

Genetic testing is strongly recommended for:
Women aged 35 years and above
Couples with a family history of genetic disorders
Carriers of known genetic mutations (thalassemia, SMA, cystic fibrosis, etc.)
Patients who have experienced 2 or more miscarriages
Couples with repeated IVF failure (2+ failed cycles)
Men with severe male factor infertility
Couples with a previously affected child

The Genetic Testing Process at Ayuh — Step by Step

Step 1 — Genetic Counselling:

You meet with our fertility specialist and genetic counsellor to understand your family history and determine which tests are right for you.

Step 2 — IVF Cycle & Embryo Development:

Your IVF cycle is carried out as normal — egg retrieval, fertilisation, and embryo development in our state-of-the-art embryology lab.

Step 3 — Embryo Biopsy:

On Day 5 (blastocyst stage), our trained embryologist carefully biopsies 5–8 cells from the trophectoderm (outer layer) of each embryo. The embryo itself is not harmed.

Step 4 — Genetic Analysis:

Biopsied cells are sent to our accredited genetics laboratory for NGS or PCR-based analysis. Results are typically available in 2–7 working days.

Step 5 — Embryo Transfer:

Based on results, your doctor recommends the best genetically normal embryo for transfer, maximising your chances of a healthy pregnancy.

Benefits of Genetic Screening in IVF

Higher IVF success rates per transfer
Significant reduction in risk of miscarriage
Prevention of heritable genetic diseases in your child
Avoidance of unnecessary embryo transfers
Emotional peace of mind before and during pregnancy
Better family planning for carriers of genetic conditions

✅ FAQs | Best IVF Centre in Ahmedabad

Find answers to common questions about IVF treatments, success rates, and fertility care at Ayuh Fertility Centre, Ahmedabad.

Q1: What is the difference between PGT-A, PGT-M, and PGT-SR?

PGT-A tests embryos for chromosomal number abnormalities. PGT-M tests for specific inherited single-gene disorders such as thalassemia. PGT-SR tests for structural chromosomal rearrangements in parents that can affect embryos. Your doctor at Ayuh will recommend the right test based on your medical and family history.

Q2: Is genetic testing mandatory before IVF in India?

Genetic testing is not legally mandatory before IVF in India, but it is strongly recommended for couples with a family history of genetic disorders, repeated miscarriages, or advanced maternal age. The ICMR-ART guidelines also support its use in high-risk couples.

Q3: Does embryo biopsy for PGT harm the embryo?

No. The biopsy is performed at the blastocyst stage (Day 5), where only a few cells from the outer layer (trophectoderm) are removed. These cells form the placenta, not the baby. Multiple studies confirm that PGT biopsy does not reduce the embryo's viability or developmental potential.

Q4: What is the cost of genetic testing for IVF in Ahmedabad?

The cost of PGT varies depending on the type of test (PGT-A, PGT-M, or PGT-SR) and the number of embryos tested. For an accurate, personalised quote, please contact Ayuh Fertility Centre directly or book a free consultation with our specialist.

Q5: Can genetic testing prevent miscarriage?

Yes. Chromosomal abnormalities in embryos are the most common cause of first-trimester miscarriage. PGT-A identifies chromosomally normal embryos for transfer, which significantly reduces the risk of miscarriage, particularly in women over 35 or those with a history of pregnancy loss.

At Ayuh Fertility Centre, we understand that the journey to parenthood isn’t just about treatment — it’s about trust, hope, and emotional healing. We walk beside you at every stage, from diagnosis to delivery, helping you move closer to the joy of holding your baby in your arms.
Because every miracle begins with a little hope — and we’re here to nurture that hope with science, care, and love.