ICSI (Intracytoplasmic Sperm Injection) is one of the most advanced fertility techniques used worldwide, particularly for male-factor infertility. In this procedure, a single healthy sperm is carefully selected and directly injected into an egg to achieve fertilisation. Over the years, ICSI treatment in Ahmedabad has become a highly effective solution for couples struggling with severe sperm-related issues, previous IVF failure, or unexplained infertility.
This guide explains how ICSI works, when it is recommended, and who benefits most from this treatment.
If you want to understand the IVF Cost before learning about ICSI, you can read our detailed IVF Cost guide here:
👉 IVF Cost in Ahmedabad
What Is ICSI and How Does It Work?
ICSI is an advanced laboratory procedure performed during IVF. Instead of allowing sperm to penetrate the egg naturally, embryologists choose one healthy sperm and inject it directly into the egg using a microscopic needle.
This technique is highly effective for couples struggling with sperm-related fertility issues. It ensures that even extremely low sperm counts or poor motility do not prevent fertilisation.
ICSI Process Step by Step
- Eggs are retrieved through a standard IVF procedure.
- Sperm is collected and prepared in the laboratory.
- Embryologists select the best sperm under a microscope.
- A single sperm is injected directly into each mature egg.
- Fertilisation is monitored for 24 hours.
- Embryos are cultured for 3–5 days and then transferred.
This level of precision is what makes ICSI treatment in Ahmedabad highly successful for many couples.
When Is ICSI Recommended?
ICSI is not required in every IVF cycle. It is specifically recommended when fertilisation is likely to fail due to male-factor infertility or certain medical conditions.
Below are the most common medical indications.
1. Very Low Sperm Count (Oligospermia}
If sperm concentration is below normal levels, natural fertilisation becomes difficult. ICSI bypasses this issue by manually selecting a sperm cell.
2. Poor Sperm Motility (Asthenozoospermia)
Sperm may be unable to reach or penetrate the egg.
ICSI ensures fertilisation by injecting sperm into the egg directly.
3. Abnormal Sperm Morphology (Teratozoospermia)
Abnormal head, tail, or midpiece structure can prevent natural fertilisation.
ICSI selects the healthiest sperm, improving fertilisation chances.
4. Zero or Very Low Sperm Count (Azoospermia)
In cases where sperm must be retrieved surgically:
- TESA (Testicular Sperm Aspiration)
- PESA (Percutaneous Epididymal Sperm Aspiration)
ICSI becomes essential because these sperm cannot fertilise eggs naturally.
5. Previous IVF Cycle With Failed Fertilisation
If an earlier IVF attempt showed poor or no fertilisation, ICSI provides a more controlled and precise fertilisation method.
6. Use of Frozen Sperm
Frozen sperm may lose motility after thawing.
ICSI increases the chances of success with frozen samples.
7. Use of Donor Eggs
To maximise fertilisation, donor cycles often include ICSI.
8. Unexplained Infertility
When no clear cause of infertility is found, ICSI ensures fertilisation despite unknown barriers.
How ICSI Improves Male Infertility Treatment
Male infertility is more common than most couples realise. According to CDC ART research, nearly 40–50% of infertility cases involve male-factor issues.
ICSI provides significant advantages by:
- Eliminating the need for high sperm count
- Bypassing motility issues
- Avoiding natural fertilisation barriers
- Enabling fertilisation even from surgically retrieved sperm
- Improving outcomes in severe male-factor infertility
These benefits have made ICSI treatment in Ahmedabad a preferred option for many couples struggling with sperm abnormalities.
Success Factors in ICSI Treatment
1. Age and Egg Quality
Egg quality plays a crucial role in embryo development.
2. Sperm Selection
Only the healthiest sperm are chosen.
3. Laboratory Standards
ICSI requires advanced microscopes, stable incubators, and cleanroom conditions.
4. Embryologist Expertise
Experience significantly affects fertilisation quality.
5. Uterine Receptivity
A healthy uterus is essential for implantation after embryo transfer.
ICSI vs. Conventional IVF – What’s the Difference?
| Feature | IVF | ICSI |
|---|---|---|
| Fertilisation | Natural sperm penetration | Sperm injected directly |
| Best For | General infertility | Severe male infertility |
| Lab Complexity | Standard | Advanced |
| Success in Male Factor | Moderate | Very high |
In many cases, combining IVF with ICSI provides one of the most effective IVF solutions for couples who struggle with fertilisation barriers.
Does ICSI Increase Pregnancy Success Rates?
ICSI improves fertilisation success, but pregnancy success depends on:
- embryo quality
- uterine health
- age
- hormonal balance
- embryo transfer conditions
While ICSI cannot “fix” embryo genetics, it greatly increases the likelihood of normal fertilisation, especially when male infertility is present.
Risks and Considerations
ICSI is a highly safe and well-established technique.
However, couples should be aware of:
- Risk of no fertilisation if eggs are weak
- Higher lab cost compared to IVF
- Need for skilled embryologists
- Possible need for multiple cycles depending on age
A transparent clinic will discuss all benefits and risks beforehand.
Cost of ICSI Treatment in Ahmedabad
ICSI may be:
- included in IVF packages, or
- billed separately
Cost varies depending on:
- number of eggs injected
- lab technology
- male-factor complexity
For a detailed breakdown of IVF cost components, read this Blog:
IVF Cost in Ahmedabad
FAQ | ICSI Treatment
1: What is ICSI treatment and how does it work?
ICSI (Intracytoplasmic Sperm Injection) is an advanced IVF technique where a single healthy sperm is directly injected into an egg. This increases the chances of fertilization, especially in couples facing severe male infertility. At Ayuh Fertility Centre, Dr. Krupa Shah uses modern micromanipulation tools and careful embryo culture to ensure the highest safety and accuracy during ICSI, making the process smooth and reliable for couples who need specialized help.
2: When is ICSI treatment recommended for couples?
ICSI is commonly recommended when there are issues like low sperm count, poor sperm motility, abnormal sperm shape, previous failed IVF cycles, or difficulty with sperm penetration. It is also suggested when sperm must be retrieved surgically. At Ayuh Fertility Centre, the doctor evaluates both partners’ reports before advising ICSI so that couples don’t undergo unnecessary procedures and get the most suitable treatment plan.
3: Who benefits the most from ICSI treatment ?
ICSI is highly beneficial for couples dealing with male-factor infertility, unexplained infertility, or very low fertilization rates in earlier IVF attempts. It also helps couples using frozen sperm or donor sperm. At Ayuh Fertility Centre, many couples with long-standing infertility have achieved pregnancy through personalized ICSI treatment designed by Dr. Krupa Shah based on their unique medical background.
4: Is ICSI treatment safe for the baby and the mother?
Yes, ICSI is considered safe and is widely practiced across the world. Millions of healthy babies have been born through ICSI. The technique does not harm the egg or increase major health risks for the baby. At Ayuh Fertility Centre, strict lab protocols, expert embryologists, and advanced embryo monitoring ensure a safe, ethical, and risk-controlled environment throughout the treatment.
5: What is the success rate of ICSI treatment at Ayuh Fertility Centre?
The success rate of ICSI depends on factors like the woman’s age, egg quality, sperm parameters, and overall reproductive health. However, with advanced lab facilities, careful embryo selection, and customized treatment protocols by Dr. Krupa Shah, Ayuh Fertility Centre consistently achieves strong pregnancy outcomes. Couples also receive counselling, diet guidance, and emotional support, which further enhance the overall success journey.
Conclusion
ICSI has transformed infertility treatment by offering precise and effective fertilisation for couples with severe male-factor infertility and complex fertility challenges. As one of the most advanced laboratory procedures, ICSI treatment in Ahmedabad provides a reliable solution when sperm quality, quantity, or function restricts natural conception.
